منابع مشابه
2-Hydroxyglutarate is not a metabolite; D-2-hydroxyglutarate and L-2-hydroxyglutarate are!
In the recent study by Wang et al. (1), the prognostic significance of the assessment of serum 2-hydroxyglutarate (2-HG) concentrations in acute myeloid leukemia was investigated. The authors report that in 87% of the patients with high serum concentrations of 2-HG, mutations in isocitrate dehydrogenase (IDH)1/IDH2 occurred, versus 29% in the group with moderately high 2-HG concentrations. This...
متن کاملUrine 2-Hydroxyglutarate in Glioma
We congratulate Fathi et al. [1] for their effort to analyze the oncometabolite 2-hydroxyglutarate (2-HG).This is an interesting work evaluating 2-HG in serum, urine, and cerebrospinal fluid (CSF) from patients with isocitrate dehydrogenase (IDH) mutant and IDH wild-type (WT) glioma. The objective of this study was to use 2-HG as a surrogate biomarker for IDH mutation. Serum 2-HGwas found to be...
متن کاملHuman Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate
Human d-3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme in the serine biosynthetic pathway, is genomically amplified in tumors including breast cancer and melanoma. In PHGDH-amplified cancer cells, knockdown of PHGDH is not fully rescued by exogenous serine, suggesting possible additional growth-promoting roles for the enzyme. Here we show that, in addition to catalyzing oxidation of...
متن کاملThe Enzymology of 2-Hydroxyglutarate, 2-Hydroxyglutaramate and 2-Hydroxysuccinamate and Their Relationship to Oncometabolites
Many enzymes make "mistakes". Consequently, repair enzymes have evolved to correct these mistakes. For example, lactate dehydrogenase (LDH) and mitochondrial malate dehydrogenase (mMDH) slowly catalyze the reduction of 2-oxoglutarate (2-OG) to the oncometabolite l-2-hydroxyglutarate (l-2-HG). l-2-HG dehydrogenase corrects this error by converting l-2-HG to 2-OG. LDH also catalyzes the reduction...
متن کاملThe oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
The identification of cancer-associated mutations in the tricarboxylic acid (TCA) cycle enzymes isocitrate dehydrogenases 1 and 2 (IDH1/2) highlights the prevailing notion that aberrant metabolic function can contribute to carcinogenesis. IDH1/2 normally catalyse the oxidative decarboxylation of isocitrate into α-ketoglutarate (αKG). In gliomas and acute myeloid leukaemias, IDH1/2 mutations con...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2021
ISSN: 2296-634X
DOI: 10.3389/fcell.2021.651317